GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11190604 | 1 | rs11190602 | chr10:102297256 | SEC31B | chr10:102246403-102289636:- | -0.3 | -11.22 | 1.05E-27 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs11190604 | 1 | rs11190604 | chr10:102302457 | SEC31B | chr10:102246403-102289636:- | -0.28 | -10.2 | 2.19E-23 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs11190604 | 1 | rs11190607 | chr10:102303614 | SEC31B | chr10:102246403-102289636:- | -0.29 | -10.75 | 1.18E-25 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs11190604 | 1 | rs11190613 | chr10:102313997 | SEC31B | chr10:102246403-102289636:- | 0.28 | 10.52 | 1.08E-24 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs4409766 | 1 | rs11191416 | chr10:104604916 | SFXN2 | chr10:104474298-104498946:+ | 0.24 | 4.71 | 2.8E-6 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| BRCA | cis | rs4409766 | 1 | rs11191416 | chr10:104604916 | TMEM180 | chr10:104221170-104238858:+ | -0.22 | -4.05 | 5.55E-5 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| BRCA | cis | rs11191419 | 1 | rs11191419 | chr10:104612335 | AS3MT | chr10:104613967-104661653:+ | -0.25 | -6.92 | 7.63E-12 | Schizophrenia |
| BRCA | cis | rs11191419 | 1 | rs11191419 | chr10:104612335 | C10orf32 | chr10:104613967-104624718:+ | -0.25 | -9.18 | 2.21E-19 | Schizophrenia |
| BRCA | cis | rs11191419 | 1 | rs11191419 | chr10:104612335 | SFXN2 | chr10:104474298-104498946:+ | -0.12 | -3.53 | 0.000437 | Schizophrenia |
| BRCA | cis | rs4409766 | 1 | rs11191425 | chr10:104625970 | SFXN2 | chr10:104474298-104498946:+ | -0.23 | -4.34 | 1.59E-5 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| BRCA | cis | rs4409766 | 1 | rs11191425 | chr10:104625970 | TMEM180 | chr10:104221170-104238858:+ | 0.2 | 3.62 | 0.000304 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| BRCA | cis | rs7078160 | 1 | rs11197899 | chr10:118861724 | KIAA1598 | chr10:118644308-118886097:- | 0.14 | 3.47 | 0.000535 | Nonsyndromic cleft lip with or without cleft palate;Orofacial clefts |
| BRCA | cis | rs12220777 | 1 | rs11201799 | chr10:81881954 | LOC219347 | chr10:81805991-81838949:- | -0.53 | -9.46 | 1.89E-20 | Chronic obstructive pulmonary disease-related biomarkers |
| BRCA | cis | rs7726354 | 1 | rs112032073 | chr5:56270717 | MAP3K1 | chr5:56110900-56191976:+ | -0.25 | -4.18 | 3.16E-5 | Breast cancer (early onset) |
| BRCA | cis | rs1867631 | 1 | rs11208927 | chr1:67089561 | TCTEX1D1 | chr1:67218140-67244729:+ | 0.12 | 3.53 | 0.000428 | Menopause (age at onset) |